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MNT is the registered trade mark of Healthline Media. These include: Usually, home care techniques can help, such as washing the eyelids and applying a warm compress to loosen any crusting. 11-cis-retinal binds opsin and holds the photoreceptor in its stable, inactive form. As a result, there is an overproduction of thyroid hormones resulting in symptoms such as tachycardia, unintended weight loss, anxiety, irregular menstrual cycles, and heat intolerance. @2018 - PenNews. Multiple Sclerosis Journal. To treat shingles, a doctor may prescribe: Learn more about shingles of the eye here. Express. Vitamin B1, also known as thiamine, has a role in pyruvate dehydrogenase multiple enzyme complex in the Krebs cycle, enzymatic processes in brain function and interneuonal communication, and the regulation of immune cells and proteins. I now have no problems with blepharitis . This page has been accessed 14,839 times. Hopefully, the above information has clarified things for you. Optometric Management describes meibomitis as a condition that affects the oil glands in our eyelids, causing dry eyes. And there are four signs of dry eyes you should be wary of, according to the NHS. Egg yolk, meat, offal and milk contain small amounts but the levels can vary during the different seasons. Fraunfelder FW, Fraunfelder FT. How is a chalazion different from a stye? There are different types of glaucoma. Bloodshot eyes - If you havent had any alcohol, bloodshot eyes are usually caused by a vitamin B2 deficiency. The newspaper is not affiliated with any political parties and has always striven to maintain its independence. It can also be treated with antibiotic eye drops, ointments or pills that are available by prescription only. Healthcare professionals believe that bacteria in the skin may be responsible for blepharitis. We avoid using tertiary references. This video is meant to expand your general knowledge about living a healthy life and is NOT a substitute for seeking medical advice. Home remedies for bloodshot eyes. mrsmop libralady13. Wensing B, et al. Many of them are no more than a minor inconvenience. The skin around your eyelids may loosen naturally as you age, creating the appearance of extra skin around your eyes. Food sources of the vitamin include meat, poultry . Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Habif, T. Bacterial Infections. Cellulitis: All you need to know. (2018). What are the symptoms of dry eyes due to allergies? Date First Available : August 28, 2017. These glands secrete oil to keep a film of tears moistening the eye. It should not be used to self-diagnose and it is not a substitute for a medical exam, cure, treatment, diagnosis, and prescription or recommendation. Eyes contour the face and red peri orbital circles can easily be spotted. 6. Iron deficiency anemia is a condition where the blood is lacking red blood cells. Blurred Vision. They may also examine your eye. Another symptom of a deficiency in this vitamin is a completely smooth tongue. However, if you have subconjunctival hemorrhage and your vision is decreased, talk with a doctor. His use of doctor or Dr. in relation to himself solely refers to that degree. Redness of the eye, also called bloodshot eyes, can indicate the presence of several different health issues. Consult an. There is no indication for large doses of vitamin C supplementation for eye health (above 2g per day) or the use of vitamin C eyedrops due to increased renal excretion. red rimmed eyes vitamin deficiency. When you lack vitamin B12, your eyes are likely to appear pale or with a slight . It is typically caused by a staph infection that is almost always curable with antibiotic oi Blepharitis gets worse when its hotter, as people age and as people fail to keep their eyelids clean. Thiamine is absorbed in the jejunum and transported in erythrocytes and plasma in the blood.10,11, In less developed countries, malnutrition is the source of thiamine deficiency. This chapter reviews the major vitamins and their various clinical presentations. We might use your IP address and browser type to help analyze usage patterns and diagnose problems on this Site and improve the service we offer to you. If the oil production is disrupted, the glands will become clogged. It is really the wrong . So, if you have other signs of iron deficiency such as pale . Get prescriptions or refills through a video chat, if the doctor feels the prescriptions are medically appropriate. Chylomicron secretion is necessary for vitamin E absorption. Vitamin deficiency can also cause depression, and in severe cases, vitamin B12 deficiency may cause confusion, forgetfulness or even personality changes. A deficiency of vitamin B12 can result in spasticity, shaky movements, muscle weakness, vision problems including eye twitches and hypotension. Dark circles under your eyes are common. However, if you have a condition that causes vision changes, this may affect your ability to perform tasks such as cooking or driving. Efficacy of two vitamin E formulations in patients with abetalipoproteinemia and chylomicron retention disease. Brown BD, Hood Watson KL. Collins MD, Mao GE. 11. June 30, 2022 . Dry eye is a condition in which the eyes do not produce enough tears to lubricate the eyes properly. Dry eyes, or the inability to produce tears is one of the first signs of vitamin A deficiency. Other symptoms to be aware of are: Angle-closure glaucoma happens when your iris blocks the area through which eye fluid drains. World Health Organization. So, what causes low vitamin B2? Blood clots block the blood vessels and cause necrosis, where an area of skin is destroyed. If exposure does occur. According to the American Optometric Association, blepharitis is a condition where the eyelids become inflamed 1. It can cause the skin to become flushed and itchy. They found that Graves disease patients with TED had a lower 25(OH)D levels than Graves disease patients without TED. Without enough vitamin A, your eyes cannot produce enough moisture to keep them properly lubricated. Infertility: Vitamin A plays an important role in your reproductive system. In turtles, most respiratory tract infections are caused by bacteria and are often secondary to vitamin A deficiency. Certain health issues that cause this redness require swift medical attention. What are the complications of eye redness? Vision loss and blindness can occur. This can damage your optic nerve, potentially leading to vision loss. Yellow Skin And Vitiligo - Vitamin B12 Deficiency. Severe cases show up as cracks in the corners of the mouth and a swollen, red tongue. It can affect the outside or inside of either your upper or lower eyelid. When the eye rim becomes red, it will generally also be irritated and sore. Meanwhile, low iron levels are also associated with hair loss, she explains. It's not just your computer that could be causing your tired and strained eyes. Some other symptoms that may occur with conjunctivitis are: Conjunctivitis can have a variety of causes, including: Conjunctivitis due to a viral or bacterial infection is very contagious. Cellulitis. Instead, its typically caused by malabsorption. Some common allergy triggers include . Vitamin B12 deficiency is associated with pernicious anemia and may cause retinal . Your eyes need fluid to clean and renew. The supplement supports artery health, and it can help strengthen your bones, in addition to potentially helping with dark circles under the eyes. 2019;53(2):113-122. doi:10.5603/pjnns.a2019.0015. Currently, there is no cure for shingles, but prompt treatment with prescription medications reduces the risk of complications and speeds recovery. More info. European Thyroid Journal. 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In the eye area, this issue can be very serious and worsen without prompt treatment.Contact a doctor right away if there are symptoms of cellulitis of the eye. Vitamin B-2, also known as riboflavin, has a number of roles throughout your body, and a deficiency might cause a number of side effects, such as digestive problems, mouth sores and tongue swelling. Macrocytic anemia refers to macrocytosis (mean corpuscular volume (MCV) greater than 100 fL) in the setting of anemia (hemoglobin less than 12 g/dL or hematocrit (Hct) less than 36% in nonpregnant females, hemoglobin less than 11 g/dL in pregnant females, or hemoglobin less than 13 g/dL or Hct less than 41% in males). Some authors feel that higher levels of vitamin D may potentially lead to better outcomes.16,17, Graves disease is an autoimmune thyroid disorder that most commonly affects women (6:1). The same deficiency may also cause cracked or chapped lips, cracked mouth corners, an oily nose, a bright red tongue and migraines. This is because the condition can lead to vision loss if not managed. Fiftly, vitamin A is helped with the . It depends on the cause of the redness. Here's how to address it. Styes and chalazia (inflammation of the eyelid): Overview. To learn more, please visit our, It goes away without doing anything with time. This condition can cause a person to lose an eye. 2018;18(2):160163. Dry eyes at night can cause itching and vision problems. Cholesterol plaquing - This is often a genetic problem that doesnt allow you to normalize your cholesterol levels. Examples include: Its also possible for scleritis to happen due to an injury to the eye or an eye infection. If one is severely missing in the body, your eyes will bear the repercussions. Is the ketogenic diet right for autoimmune conditions? Boyd K. (2021). feeling weak or tired. DOI. Below, learn about these and other health conditions that can have this effect. Specific conditions may lead to it. Travis Sharpe began writing in 2009. The Mayo Clinic describes cellulitis as a potentially dangerous skin infection that is caused by bacteria 2. For each one, well cover what it is, what causes it, and any other additional symptoms to be aware of. Cham: Springer International Publishing; 2018. J Infect. (2021). Believe it or not, a vitamin B2 deficiency isnt usually caused by failing to consume enough B2-rich foods. This is why red eye circles may be classified under dark under eye circles. Connect with a U.S. board-certified doctor by text or video anytime, anywhere. #keto #ketodiet #weightloss #ketosisThanks for watching. Vitamin A deficiency is the leading cause of preventable blindness . That means that it can easily be spread from one person to another. If you disable this cookie, we will not be able to save your preferences. As such, a shortage in iron is often associated with anemia, although it's possible to suffer iron . Can diet help improve depression symptoms? Vitamin A deficiency stops the production of these pigments, leading to night blindness. Some potential causes of subconjunctival hemorrhage are: You may be more prone to this condition if youre taking blood thinners or have diabetes or hypertension. Tears are made by small glands above the eyes. See your eye doctor for a recommendation of whi , you are lucky to be alive, and the redness of your eyes can probably be evaluated electively by your doctor. Skin issues: A lack of vitamin A can cause dry, scaly and/or itchy skin. A very high intake of vitamin A over a long period of time can cause problems such as rough skin, dry hair and an enlarged liver. 2017;381:213-219. doi:10.1016/j.jns.2017.07.046. Strictly Necessary Cookie should be enabled at all times so that we can save your preferences for cookie settings. It will appear as a pimple or boil with a white head on the edge of the eyelid near the eyelash follicles. Anaemia is the general term for having either fewer red . New York: Mosby, 2008: 1075-1084. Number 14. Unexplained weight loss. Appearance may vary depending on skin tone from dark red, brownish purplish or dark blue. Over the past 70-plus years, the Cyprus Mail, with a small dedicated team, has covered momentous events in Cyprus modern history, chronicling the last gasps of British colonial rule, Cyprus truncated independence, the coup and Turkish invasion, and the decades of negotiations to stitch the divided island back together, plus a myriad of scandals, murders, and human interests stories that capture the island and its -people. In addition to the causes discussed above, some further causes of eye redness include: If your eye redness is caused by a milder condition such as allergies, conjunctivitis, or blepharitis, you may be able to treat your symptoms at home. What is glaucoma? Vitamin D deficiency - does your hair look like this? problems with memory, understanding and judgment (cognitive changes) Some of these symptoms can also happen in people who have a vitamin B12 or folate deficiency but have not developed anaemia. Xerophthalmia continues to be a leading cause of preventable blindness in developing countries[1]. Tea contains antioxidants and flavonoids. 2012;64(2):148055. doi: 10.1016/j.jinf.2011.11.004. A systematic review of bacteremias in cellulitis and erysipelas. Vitamin B1: Deficiency of vitamin B1 causes beriberi, which results in weak muscles and severe weight loss. Benzimra JD, Simon S, Sinclair AJ, Mollan SP. Vitamin D enters the circulation from the skin or lymphatic system and goes to the liver for processing. For example, a vitamin D deficiency can lead to weak bones and fractures, while a folate deficiency . It does not create a doctor-patient relationship between Dr. Berg and you. Turtles with respiratory infections may have excess mucus in their mouths (seen as bubbles in the mouth, nose, and eyes), nasal discharge, lethargy, loss of appetite, wheezing, extension of the neck to breathe, and open-mouth . While some of these issues are benign, others are serious and require emergency medical attention. Dermatology. 2012 Feb;64(2):148055. doi: 10.1016/j.jinf.2011.11.004. In industrialized countries, such as the U.S., thiamine intake is high because of the abundance of enriched, fortified and whole-grain products. Vitamin B12-deficiency anemia, also known as cobalamin deficiency, is a condition that develops when your body can't make enough healthy red blood cells because it doesn't have enough vitamin B12. Tea bags. Some of these include: In addition to eye redness, some symptoms of complications related to contact lenses are: If you wear contact lenses and have any of the symptoms above, remove your contacts for a few hours. Management of Wernicke Encephalopathy and thiamine deficiency can be found here. 1. Sight-threatening pseudotumour cerebri associated with excess vitamin A supplementation. He also told me not to use any creams at all on my eyes. Summarising the findings of the study, the researchers said: To our knowledge, our study is the first to demonstrate the association between dry eye and clinical parameters of hypovitaminosis D such a fatigue, functional impairment and pain., They added: We are of the opinion that vitamin D plays a protective role in the development of dry eye, probably by enhancing tear film parameters and reducing ocular surface inflammationvitamin D supplementation may be useful for dry eye symptoms, including ocular discomfort, soreness, redness, ocular fatigue, sensitivity to light and blurred vision.. Neuro-Ophthalmology. Clinical Dermatology, 4th Edition. Each of the reasons indicates either an infection or sterile inflammation of that tissue. These cookies may track things such as how long you spend on the Site and the pages that you visit so that we can continue to produce engaging content. All rights reserved. // Leaf Group Lifestyle, American Optometric Association: Blepharitis, Raff AB, Kroshinsky D. Cellulitis: A review. EyeWiki. Your body needs vitamin B12 to make healthy red blood cells, white blood cells, and platelet. Vitamin A is essential for various life processes such as reproduction, embryo development, growth, cell differentiation, immune function, and vision.1 Preformed vitamin A sourced from animal foods (e.g., liver, egg yolks) and provitamin A carotenoids sourced from plant foods (e.g., dark green leafy vegetables, carrots, papaya) or supplements undergo metabolism in the intestine resulting in conversion into retinol. These conditions can be irritating to have, and one of them can become a potentially sight-threatening condition. For eye conditions such as macular degeneration, we recommend 5,000 IU per day, or as prescribed by your doctor. Luckily, there are some really simple ways to get the vitamins and nutrients your eyes need. (2019). You can learn more about how we ensure our content is accurate and current by reading our. Preventive Nutrition The Comprehensive Guide for Health Professionals. Vitamin E and oxidative stress in abetalipoproteinemia and familial hypobetalipoproteinemia. We use cookies for a variety of reasons detailed below. Scleritis is when inflammation affects the white of your eye, which is called the sclera. red rimmed eyes vitamin deficiency. 4. Early recognition and prompt vitamin replacement may be vision or lifesaving. Cellulitis. You ask, we answer: Can dry eye cause blindness? Designed and Developed by. The Association of UK Dieticians recommends nine foods to eat to help your body get vitamin D: Oily fish - this includes salmon, sardines, pilchards, trout, herring and kippers. 5. A recent 2015 study found that the combination of oral vitamin B12 supplements and artificial tears improved symptoms of dry eye syndrome. As such, theyre at an increased risk of eye redness due to a variety of factors. This can develop from a break in the skin that allows bacteria to enter the area. April 2017. doi:10.1136/bcr-2017-220024. Copyright 2023 Leaf Group Ltd., all rights reserved. This vitamin deficiency can do it too!One of the Best Sources of Vitamin B2, . In one type, called angle-closure glaucoma, a rapid increase in eye pressure occurs. The Mayo Clinic describes cellulitis as a potentially dangerous skin infection that is caused by bacteria 2 3. Eye allergies are often triggered by substances in the air, such as pollen or dust. It is most commonly caused by an overgrowth of one species of the many species of bacteria that normally live on our bodies. Red inner eyelid - This is often a blood sugar issue. Healing Foods: Salmon, red meat, fortified cereal, yogurt, and swiss cheese. As usual, blood vessels are invisible, but once eyes are irritated by bacteria or germs, the capillaries would get dilated and visible, so eyes are red. It usually affects the skin on the lower legs, but it can appear on the face, including the areas around the eyes. According to the study reported in PubMed Central, called " Dry eye in vitamin D deficiency: more than an incidental association ", it was shown that vitamin D . Thiamin Function, Metabolism, Uptake, and Transport. At Healthfully, we strive to deliver objective content that is accurate and up-to-date. Corneal ulcers are ulcers, or sores, that affect the outer part of your eye, which is called the cornea. Vitamin B12 Deficiency. target no need to return item. Vitamin C may provide a boost of brightness and antioxidant power to your face if you have thinning, dry skin or visible veins. While the best source of the vitamin is from sunlight, it can also be gained by eating certain foods. As it was previously mentioned, if you are not sure whether you want to allow the cookies or not, it is usually safer to leave cookies enabled in case it interacts with one of the features you use on our Site. Folate, vitamin B12 and niacin can all claim responsibility for the abnormally smoothed tongue called "atrophic glossitis," depending on your clinical situation. Vitamin B12, a water-soluble vitamin, helps the body make DNA and nerve cells. Wernicke Encephalopathy. Treatment for this condition can include over-the-counter remedies such as hot compresses, fish oil or flax seed oil supplements, or prescription medications such as oral antibiotics. Dr. William Goldstein answered. Eczema (atopic dermatitis) overview. Bendich A, Deckelbaum RJ. Some additional symptoms of blepharitis are: Its also possible for blepharitis to cause more serious symptoms, particularly if not managed. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Medication-Induced Intracranial Hypertension in Dermatology. Vitamin D deficiency symptoms: Look for this sign in your teeth, Vitamin D deficiency - the best drink to add to your morning routine, Vitamin D deficiency symptoms: Four signs in your eyes could indicate the condition, Vitamin D deficiency - the amount of sunlight you need every day, Vitamin D deficiency: Five easy ways to avoid the condition, Vitamin D deficiency symptoms: Dry eyes has been found in studies to be a sign, Vitamin D deficiency symptoms: Temporarily blurred vision can be an indicator, Vitamin D deficiency symptoms: Signs not associated with condition. Try not to use visine -type drops. Moisturizing the skin every day and applying over-the-counter topical treatments may also help ease the symptoms or prevent them from developing. We avoid using tertiary references. You can develop bloodshot eyes because of several different health issues. Symptoms, causes, diagnosis, treatment. Could you tell me what's the best way to avoid red rimmed eyes? Best Sellers Rank: #200,009 in Health & Household ( See Top 100 in Health & Household) #1,266 in Vitamin D Supplements. Vitamin K. Dark eye circles aren't solely caused by a lack of vitamin B. Dermatologist Dr. Tabitha Craine, MD says that a vitamin K deficiency is a common cause for sleepy-looking under-eyes. Allergies are a very common cause of red eyelids. "V itamin K is responsible for strengthening veins and capillaries, and it also promotes healthy circulation and is essential for proper blood . A lack of vitamin A can make your eyes dry. (2020). The major source of vitamin D is sunlight. It is absorbed in the intestinal lumen, which is dependent upon various factors such as pancreatic secretions, micelle formation, and most importantly, chylomicron secretions. This is usually the result of a gallbladder problem. What are the common causes of eye redness? This turns your eyes and/or skin yellow. International Ophthalmology Clinics. Depending on your diagnosis, the doctor may prescribe treatment that helps to alleviate your symptoms. Warfarin is an anticoagulant medicine (blood thinner). Deficiency is typically due to limited sunlight exposure. A lack of this vitamin can lead the skin to suffer, and promote feelings of fatigue. Ocular manifestations are common in multiple sclerosis with 20% initially presenting with optic neuritis. 2018;24(1):80-85. doi:10.1177/1352458517737373. Symptoms vary from person to person, but some of the most common include: Genetic variations, environmental factors, irritants, and allergens are the primary causes of eczema. Learn more about them and their related symptoms and treatments here. They are generally caused by poor eyelid hygiene and ongoing blepharitis or meibomitis. Vitamin C Crash Course. Vitamin B12 helps keep your blood and nerve cells healthy and also plays a role in the making of your genetic material or DNA. Ill see you in the next video. Graves disease is treated with antithyroid medications or partial or total removal of the thyroid. We describe other symptoms to be aware of and when to contact a doctor. These can be extremely painful. In various reports, PTC, although rare, is attributed to the use of retinoids for acne (e.g., isotretinoin), psoriasis, and in leukemia6, excessive dietary7 (e.g., liver ingestion) and supplement intake.8 All-trans retinoic acid used for acute promyelocytic anemia has also been linked to the presentation of IIH.9. Top answers from doctors based on your search: Created for people with ongoing healthcare needs but benefits everyone. Multiple sclerosis. That's why it's best to take your biotin as part of a B-complex, she says. Smith J., et al. In severe stages of Vitamin A deficiency, keratomalacia may develop and this ulceration of the cornea can lead to blindness. Google Analytics is Googles analytics tool that helps our website to understand how visitors engage with their properties. Inflammation of the conjunctiva causes the whites of your eyes to appear pink or red in color. Blepharitis is inflammation at the base of the eyelashes. Vitamin . A person with severe vitamin D decency is at increased risk of loss of bone density and fractures. This would likely include things like: Most causes of eye redness wont result in serious complications. Vitamin D and Selenium in a Thyroid Eye Disease Population in Texas. Vitamin A - vitamin A is an anti-oxidant which acts as a fab anti-ageing vitamin as well. Overview. Meta-rhodopsin II production leads to a sequence of events resulting in a change in neurotransmitter release that is communicated to other retinal neurons and ultimately the brain.2, Worldwide, vitamin A deficiency is the leading cause of preventable blindness in children, mainly affecting countries in Southeast Asia and Africa. What is dry eye and how can I get rid of it? Timestamps0:00 Nutritional Deficiency Symptoms From Eyes0:10 Yellow eyes 0:43 Bloodshot eyes 1:09 Cholesterol plaquing 1:49 Cataracts 2:14 Red inner eyelid 2:41 Stye In this video, were going to talk about how nutritional deficiencies can show symptoms in your eyes. By using our website, you consent to our use of cookies. A stye is a blockage of the meibomian gland in the eye that causes inflammation. Treasure Island (FL): StatPearls Publishing; 2019 Jan-. "One of the best ingredients to find in eye creams is vitamin C because it gets rid of free radicals and brightens the skin," says Amiruddin. Each dose was 5,000 . You might also experience eye fatigue and light . Created for people with ongoing healthcare needs but benefits everyone. Teratology of Retinoids. A hordeolum is also known as a sty. https://doi-org.ezproxy.med.cornell.edu/10.1007/978-3-642-58483-1, https://www.who.int/nutrition/topics/vad/en/, https://doi-org.ezproxy.med.cornell.edu/10.1007/978-1-59259-880-9_23, https://ohsu.pure.elsevier.com/en/publications/evidence-for-a-probable-causal-relationship-between-tretinoin-aci-2, https://www.ncbi.nlm.nih.gov/books/NBK114331/, https://eyewiki.org/Wernicke_Encephalopathy, https://eyewiki.org/w/index.php?title=Vitamins_in_Neuro-Ophthalmology&oldid=84337. W. Bacterial Diseases. An antibiotic ointment, and sometimes an antibiotic pill, are generally prescribed to fight the infection. Red eyelids may also result from trauma to the eye area. Dont wear contact lenses longer than recommended or while swimming. Vitamin D deficiency is associated with disability and disease progression in multiple sclerosis patients independently of oxidative and nitrosative stress. Numbness or tingling in your hands or feet. Uveitis is inflammation that happens in the middle part of your eye, called the uvea. According to the Mayo Clinic, a hordeolum is an infected oil gland in the eyelid 23. Dark circles. So how can you avoid a deficiency in the vitamin in the first place? In Graves disease, the thyroid-stimulating immunoglobulins bind to the thyroid gland, causing the stimulation of the thyroid-stimulating hormone receptor. Heart palpitations. Planck T, Shahida B, Malm J, Manjer J. Vitamin D in Graves Disease: Levels, Correlation with Laboratory and Clinical Parameters, and Genetics. Stye - This is also a blood sugar issue. Blepharitis is when your eyelids become inflamed. If not treated appropriately, WE can progress to Korsakoff syndrome, resulting in permanent anterograde and retrograde memory impairment.12. Over 250 million preschool children are deficient across the globe.3 In developing countries, Vitamin A deficiency is because of malnutrition meanwhile in developed countries, although rare, is due to malabsorption following intestinal and bariatric surgery.4 Other causes of vitamin A deficiency include inadequate liver stores, liver disease, and the acute phase response.5, Vitamin A deficiency can cause a spectrum of eye diseases including xerophthalmia (dryness of the conjunctiva and cornea). Photo isomerization of 11-cis-retinal to all-trans-retinal causes conformational alterations in the receptor, consequently producing meta-rhodopsin II. The common causes of the dry eye syndrome include ageing, allergies and eye fatigue. Ted's Bio; Fact Sheet; Hoja Informativa Del Ted Fund; Ted Fund Board 2021-22; 2021 Ted Fund Donors; Ted Fund Donors Over the Years. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline.